A New Strategy for the Synthesis of Nucleosides: One-Pot Enzymatic Transformation of D-Pentoses into Nucleosides

نویسندگان

  • Anatoly I. Miroshnikov
  • Roman S. Esipov
  • Irina D. Konstantinova
  • Ilja V. Fateev
  • Igor A. Mikhailopulo
چکیده

A possibility of the one-pot synthesis of purine and pyrimidine nucleosides employing pure recombinant ribokinase, phosphopentomutase and nucleoside phosphorylases in a caskade transformation of D-pentoses into nucleosides is demonstrated. Preliminary results of this study point to reliability to develop practical methods for the preparation of a number of biologically important nucleosides.

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تاریخ انتشار 2010